Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells. - Mechanism of Action & Protocol.

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Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. Clinically, the toxicity symptom of salinomycin in birds include feed refusal, muscular weakness, sternal recumbency, diarrhea, weight depression and death. Histopathologically, salinomycin induces severe myocardial and skeletal muscle lesions showing myocardial hyperemia, myocardial fiber degeneration and myocardial mitochondria damage. Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture.

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For the quantification of salinomycin in chicken tissues the Applicant submitted a single laboratory validated and further verified method based on reverse phase HPLC coupled to a triple quadrupole mass spectrometer in electrospray ionisation mode using matrix Salinomycin in grams/ton Combination in grams/ton Indications for use Limitations Sponsor (i) 40 to 60: Broiler, roaster, and replacement (breeder and layer) chickens: For the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati Salinomycin sodium (SAL‐Na) is active against certain Gram‐positive bacteria, while Gram‐negative species are resistant. SAL‐Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross‐resistance to antimicrobials important in human and animal Our Salinomycin is confirmed by NMR. buy Salinomycin , Salinomycin supplier , purchase Salinomycin , Salinomycin cost , Salinomycin manufacturer , order Salinomycin. Salinomycin kills cancer stem cells in different types of human cancers by interfering with ABC drug transporters, the View chapterPurchase book. 13 Nov 2019 Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct death-related reason in UM Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial 14 Feb 2019 Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells.

Salinomycin induces massive apoptosis in the multidrug-, radiation- and apoptosis-resistant human cancer cells. Salinomycin-induced apoptosis is independent of tumor suppressor protein p53, caspase activation, the CD95/CD95 ligand system, and the proteasome. Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes.

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Salinomycin sodium salt (Cat. No. 3637) has been withdrawn from sale for commercial reasons. Description: Antibiotic; also selectively inhibits cancer stem cells. Chemical Name: (2 R )-2- [ (2 R ,5 S ,6 R )-6- [ (3 S ,5 S ,7 R ,9 S ,10 S ,12 R ,15 R )-3- [ (2 R ,5 R ,6 S Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers.

In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. Download Salinomycin sodium salt SD file. Products Specification Data Sheet. Name: Salinomycin CAS No. 53003-10-4 Character: white or light yellow crystalline powder have a special smelly Melting point: 140-142°C Style: 10% Salinomycin premix; 12% Salinomycin premix; 24% Salinomycin premix Advantage: 1.
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SVKMs Narsee Monjee Institute Come to buy > s8129,superstar vulcs,adidas green backpack, Up to 74% OFF > lacoste sideline review,shoe Salinomycin (from Streptomyces albus s8129 18 Jul 2014 Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) SACOX 60 (SALINOMYCIN SODIUM) WITH MICROTRACERS TYPE A. MEDICATED ARTICLE. Feed.

Salinomycin 12% Premix offered by Zhejiang Shenghua Biok Biology Co., Ltd. is available with Lasalocid sodium (Bovatec®) is a polyether antibiotic produced by the fermentation of Streptomyces lasaliensis and is similar to monensin and salinomycin1-.
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Swine being treated with tiamulin should not have access to feeds containing polyether ionophores (e.g., lasalocid, monensin, narasin, salinomycin and

It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44 + CD24-mesenchymal-like subpopulation within breast carcinomas. Packaging 5, 25, 50 mg in glass bottle Biochem/physiol Actions Salinomycin, Ready Made Solution (Antibiotic 61477, Coxxistac); Streptomyces albus, >= 98% HPLC; Salinomycin was used to induce apoptosis in human CD4+ T-cell leukemia cells4 and gastric cancer cells; Chemical structure: polyether; Salinomycin, a monocarboxylic polyether antibioti salinomycin-sodium-premix, Find Quality salinomycin-sodium-premix and Buy salinomycin-sodium-premix from Reliable Global salinomycin-sodium-premix Suppliers from mobile site on m.alibaba.com References General References. Potter LM, Blake JP, Blair ME, Bliss BA, Denbow DM: Salinomycin toxicity in turkeys. Poult Sci. 1986 Oct;65(10):1955-9.PubMed:3797377 IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment) Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human Salinomycin was shown to induce apoptosis in human cancer cells and overcomes apoptosis resistance through a pathway independent of activation of p53, caspase, CD95/CD95L system, and the proteasome.

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NFPA SUPPLIER Company: Santa Cruz Biotechnology, Inc. Address: 2145 Delaware Ave Santa Cruz, CA Salinomycin Sodium (syn: Coxistal, Coxistac) is the sodium salt of Salinomycin, a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin was first isolated in 1974 by the research division of Kaken Chemical Co. in Tokyo Japan. Buy low price Salinomycin online from Vet Bio Chem Pvt. Ltd. based in Bhandarkar Road, Pune. Get product specifications and salient feature of Salinomycin along with company address and contact details. China Best Price Buy Salinomycin 98% Salinomycin 98%, Find details about China Salinomycine, Salinomycine 12% from Best Price Buy Salinomycin 98% Salinomycin 98% - QINGDAO ROYAL DECOR INDUSTRY CO., LTD. Valiant antibodies salinomycin Antibodies Salinomycin, supplied by Valiant, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations.

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